Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19330837 | 0.91 | OPRL1 (0.57) | CCR3SIGMAR1DRD2OPRL1KDM4E | |
| SCHEMBL19331018 | 0.87 | OPRL1 (0.47) | CCR3SIGMAR1OPRL1KDM4EKMT2A | |
| SCHEMBL29087368 | 0.85 | SIGMAR1 (0.52) | CCR3SIGMAR1DRD4DRD2DRD3 | |
| SCHEMBL19330960 | 0.83 | CHRM2 (0.47) | CCR3DRD4DRD2DRD3OPRL1 | |
| SCHEMBL2476831 | 0.81 | OPRL1 (0.65) | CCR3SIGMAR1DRD2OPRL1KMT2A | |
| SCHEMBL24685392 | 0.81 | KDM4E (0.46) | CCR3SIGMAR1OPRL1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL6543403 | 0.80 | POLB (0.66) | CCR3SIGMAR1DRD2OPRL1KMT2A | |
| SCHEMBL24685832 | 0.79 | CCR3 (0.61) | CCR3SIGMAR1DRD4DRD2DRD3 | |
| SCHEMBL29087358 | 0.79 | CCR3 (0.83) | CCR3SIGMAR1DRD4DRD2DRD3 | |
| SCHEMBL19331312 | 0.79 | CYP2D6 (0.49) | SIGMAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288414-A1 | SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME | Rappta Therapeutics Oy (FI) | 2023-12-13 | — | — | EP | disclosed |
| CN-116806217-A | Substituted cyclic modulators of protein phosphatase 2A (PP 2A) and methods of use thereof | 拉帕塔疗法公司 | 2023-09-26 | — | — | CN | disclosed |
| WO-2022167867-A1 | SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME | RAPPTA THERAPEUTICS OY (FI) | 2022-08-11 | — | — | WO | disclosed |