Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 11/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061692 | 1.00 | ALK (0.55) | ALKMETEGFRFLT3ROS1 | |
| SCHEMBL2061469 | 0.88 | ALK (0.59) | ALKMETEGFRFLT3ROS1 | |
| SCHEMBL2062015 | 0.86 | ALK (0.61) | ALKMETEGFR | |
| SCHEMBL2060633 | 0.85 | ALK (0.57) | ALKFLT3 | |
| SCHEMBL2061634 | 0.85 | ALK (0.57) | ALKFLT3 | |
| SCHEMBL2060635 | 0.85 | ALK (0.57) | ALKFLT3 | |
| SCHEMBL2061633 | 0.85 | ALK (0.57) | ALKFLT3 | |
| SCHEMBL2061547 | 0.85 | ALK (0.57) | ALKFLT3 | |
| SCHEMBL2914656 | 0.83 | MET (0.59) | ALKMETEGFR | |
| SCHEMBL884561 | 0.79 | ALK (0.62) | ALKMETEGFRFLT3ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |