Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062015 | 0.96 | ALK (0.61) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL2060554 | 0.90 | MET (0.70) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL885001 | 0.87 | ALK (0.71) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL2915592 | 0.86 | MET (0.67) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL884620 | 0.84 | MET (0.64) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL885245 | 0.84 | MET (0.63) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL885950 | 0.84 | MET (0.63) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL2061469 | 0.83 | ALK (0.59) | METALKMAPK8MAPK9MAPK10 | |
| SCHEMBL2908836 | 0.83 | ALK (0.55) | METALKEGFR | |
| SCHEMBL2061692 | 0.83 | ALK (0.55) | METALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |