Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | DTYMK | P23919 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923132 | 0.83 | POLB (0.55) | POLBGPR119TRPV1KITGBA1 | |
| SCHEMBL31728100 | 0.82 | MEN1 (0.43) | GPR119KITGBA1CKS1BSKP1 | |
| SCHEMBL22915106 | 0.82 | POLB (0.47) | POLBGPR119TRPV1KITGBA1 | |
| SCHEMBL3436722 | 0.81 | POLB (0.57) | POLBGPR119TRPV1KITGBA1 | |
| SCHEMBL122104 | 0.79 | GPR119 (0.56) | POLBGPR119TRPV1KITGBA1 | |
| SCHEMBL22391780 | 0.79 | POLB (0.58) | POLBGPR119KITGBA1CKS1B | |
| SCHEMBL10317314 | 0.79 | POLB (0.58) | POLBGPR119KITGBA1CKS1B | |
| SCHEMBL31046329 | 0.78 | POLB (0.57) | POLBGPR119TRPV1KITGBA1 | |
| SCHEMBL2715768 | 0.78 | POLB (0.57) | POLBGPR119TRPV1KITGBA1 | |
| SCHEMBL3213486 | 0.78 | TRPV1 (0.69) | TRPV1TRPA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112154145-B | Piperazine azaspiro derivatives | 辉瑞大药厂 | 2023-10-17 | — | — | CN | disclosed |