Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 15/20 | 0.54 |
| ▸ | MET | P08581 | 13/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885017 | 0.89 | INSR (0.58) | INSRMETALKIGF1RPTK2 | |
| SCHEMBL885116 | 0.85 | INSR (0.59) | INSRMETALKIGF1RPTK2 | |
| SCHEMBL885095 | 0.82 | MET (0.78) | INSRMETALKIGF1RPTK2 | |
| SCHEMBL2061516 | 0.82 | INSR (0.54) | INSRMETALK | |
| SCHEMBL885128 | 0.82 | INSR (0.54) | INSRMETALK | |
| SCHEMBL885082 | 0.81 | INSR (0.53) | INSRMETALK | |
| SCHEMBL885054 | 0.81 | INSR (0.54) | INSRMETALK | |
| SCHEMBL884974 | 0.81 | MET (0.61) | INSRMETALKIGF1RPTK2 | |
| SCHEMBL885145 | 0.81 | MET (0.63) | INSRMETALKIGF1RPTK2 | |
| SCHEMBL885111 | 0.80 | INSR (0.56) | INSRMETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |