Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29093590 | 1.00 | TLR8 (0.48) | TLR8KCNH2SMN1; SMN2MAPK8TLR7 | |
| SCHEMBL29093607 | 0.89 | TLR8 (0.64) | TLR8KCNH2SMN1; SMN2MAPK8TLR7 | |
| SCHEMBL29093600 | 0.89 | TLR8 (0.64) | TLR8KCNH2SMN1; SMN2MAPK8TLR7 | |
| SCHEMBL19924181 | 0.84 | TLR8 (0.54) | TLR8KCNH2TLR7ADORA2AADORA1 | |
| SCHEMBL30076088 | 0.84 | TLR8 (0.54) | TLR8KCNH2TLR7ADORA2AADORA1 | |
| SCHEMBL19924183 | 0.84 | TLR8 (0.54) | TLR8KCNH2TLR7ADORA2AADORA1 | |
| SCHEMBL29093582 | 0.81 | TLR8 (0.61) | TLR8TLR7LMNAHPGD | |
| SCHEMBL29099892 | 0.81 | TLR8 (0.34) | TLR8TLR7 | |
| SCHEMBL29099890 | 0.81 | TLR8 (0.34) | TLR8TLR7 | |
| SCHEMBL29099897 | 0.81 | AURKB (0.36) | TLR8SMN1; SMN2MAPK8LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768883-A | Pyrimido aromatic ring compounds and application thereof in medicines | 广东东阳光药业股份有限公司 | 2023-09-19 | — | — | CN | disclosed |