Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.64 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29093607 | 1.00 | TLR8 (0.64) | TLR8TLR7SMN1; SMN2LMNAHPGD | |
| SCHEMBL29093593 | 0.89 | TLR8 (0.48) | TLR8TLR7SMN1; SMN2LMNAHPGD | |
| SCHEMBL29093590 | 0.89 | TLR8 (0.48) | TLR8TLR7SMN1; SMN2LMNAHPGD | |
| SCHEMBL29093582 | 0.86 | TLR8 (0.61) | TLR8TLR7LMNAHPGD | |
| SCHEMBL18109542 | 0.84 | TLR8 (0.75) | TLR8TLR7KCNH2NLRP3 | |
| SCHEMBL18109545 | 0.84 | TLR8 (0.75) | TLR8TLR7KCNH2NLRP3 | |
| SCHEMBL30557848 | 0.84 | TLR8 (0.45) | TLR8TLR7KCNH2 | |
| SCHEMBL24060142 | 0.82 | TLR8 (0.71) | TLR8TLR7KCNH2NLRP3 | |
| SCHEMBL29093971 | 0.82 | TLR8 (0.68) | TLR8TLR7KCNH2 | |
| SCHEMBL29093970 | 0.82 | TLR8 (0.68) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768883-A | Pyrimido aromatic ring compounds and application thereof in medicines | 广东东阳光药业股份有限公司 | 2023-09-19 | — | — | CN | disclosed |