Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727634 | 0.90 | CYP1A2 (0.43) | TSHRGAAMAPTALDH1A1CYP1A2 | |
| Formic Acid SCHEMBL29653973 | 0.87 | TSHR (0.36) | TSHRGAAMAPTALDH1A1CYP1A2 | |
| Ammonia Solution, Strong SCHEMBL8205154 | 0.82 | CYP1A2 (0.35) | TSHRGAAALDH1A1CYP1A2KMT2A | |
| SCHEMBL16912862 | 0.82 | ALDH1A1 (0.39) | TSHRGAAALDH1A1CYP1A2 | |
| SCHEMBL12352241 | 0.82 | ALDH1A1 (0.39) | TSHRGAAALDH1A1CYP1A2 | |
| SCHEMBL15569964 | 0.82 | ALDH1A1 (0.39) | TSHRGAAALDH1A1CYP1A2 | |
| SCHEMBL15570217 | 0.82 | ALDH1A1 (0.39) | TSHRGAAALDH1A1CYP1A2 | |
| SCHEMBL9516918 | 0.82 | ALDH1A1 (0.39) | TSHRGAAALDH1A1CYP1A2 | |
| SCHEMBL15707671 | 0.82 | ALDH1A1 (0.39) | TSHRGAAALDH1A1CYP1A2 | |
| SCHEMBL16912864 | 0.82 | ALDH1A1 (0.39) | TSHRGAAALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1964189-B1 | COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME | GEN ELECTRIC (US) | 2010-08-18 | — | — | EP | disclosed |
| EP-1964189-A1 | COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME | General Electric Company (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007070162-A1 | COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME | GENERAL ELECTRIC COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |
| US-20070132371-A1 | Color tunable light-emitting devices and method of making the same | GENERAL ELECTRIC COMPANY (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070131949-A1 | Color tunable light-emitting devices and method of making the same | GENERAL ELECTRIC COMPANY (US) | 2007-06-14 | — | — | US | disclosed |
| US-5431697-A | Reversibly variable color patterning composition for synthetic resin articles | MATSUI SHIKISO CHEMICAL CO., LTD. (JP) | 1995-07-11 | — | — | US | disclosed |
| US-5221288-A | Treating cellulose fiber textile product with cationic compound, immersing in dispersion of microencapsulated thermochromic or photochromic material | MATSUI SHIKISO CHEMICAL CO., LTD. (JP) | 1993-06-22 | — | — | US | disclosed |
| EP-0480162-A1 | Dyeing method and dyed product | MATSUI SHIKISO CHEMICAL CO., LTD (JP) | 1992-04-15 | — | — | EP | disclosed |