SCHEMBL2909450

SCHEMBL2909450

CC(C(=O)O)N1CCNCCN2CCN(CC1)C2=O

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.36
OPRD1 P41143 8/20 0.35
ALDH1A1 P00352 3/20 0.33
USP2 O75604 1/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM1 P11229 1/20 0.33
SLC6A9 P48067 1/20 0.32
GAA P10253 1/20 0.32
CHRM5 P08912 1/20 0.32
CHRM3 P20309 1/20 0.32
KMT2A Q03164 3/20 0.32
MEN1 O00255 2/20 0.32
KDM4E B2RXH2 2/20 0.32
OPRM1 P35372 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6423403 0.88 GAA (0.37) ALDH1A1SLC6A9GAAKMT2AMEN1
SCHEMBL14100024 0.86 SIGMAR1 (0.43) SIGMAR1OPRD1CHRM2CHRM1SLC6A9
SCHEMBL6804821 0.86 SIGMAR1 (0.43) SIGMAR1OPRD1CHRM2CHRM1SLC6A9
SCHEMBL6423835 0.84 SIGMAR1 (0.42) SIGMAR1OPRD1CHRM2CHRM1SLC6A9
SCHEMBL7591281 0.84 SIGMAR1 (0.44) SIGMAR1OPRD1CHRM2CHRM1CHRM5
SCHEMBL905224 0.84 SIGMAR1 (0.44) SIGMAR1OPRD1CHRM2CHRM1CHRM5
SCHEMBL8795419 0.82 SIGMAR1 (0.43) SIGMAR1OPRD1CHRM2CHRM1CHRM5
Hydrochloric Acid SCHEMBL1184615 0.82 SIGMAR1 (0.43) SIGMAR1OPRD1CHRM2CHRM1CHRM5
SCHEMBL2910332 0.80 OPRD1 (0.38) SIGMAR1OPRD1ALDH1A1TSHRHSD17B10
Benzene SCHEMBL9148381 0.79 OPRD1 (0.44) SIGMAR1OPRD1CHRM2CHRM1CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047677-B1 Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid BRACCO SPA (IT) 2005-07-20 EP claimed
US-6342597-B1 CONDENSATION REACTION TRIETHYLENETETRAMINE WITH GLYOXAL TO CYCLIZE; OXIDATION, ALKYLATION, HYDROLYSIS, QUATERNIZATION; NUCLEAR MAGNETIC RESONANCE IMAGING DIBRA S.P.A. (IT) 2002-01-29 US claimed
EP-1602649-B1 Process for the preparation of monofunctionalized 1,4,7,10-tetraazacyclododecane BRACCO SPA (IT) 2010-08-18 EP disclosed
EP-1602649-A2 1,4,7,10-TETRAAZACYCLODODECANE-1,4-DIACETIC ACID DERIVATIVES AS CHELATING AGENTS BRACCO S.p.A. (IT) 2005-12-07 EP disclosed
EP-1047677-B1 Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid BRACCO SPA (IT) 2005-07-20 EP disclosed
US-6342597-B1 CONDENSATION REACTION TRIETHYLENETETRAMINE WITH GLYOXAL TO CYCLIZE; OXIDATION, ALKYLATION, HYDROLYSIS, QUATERNIZATION; NUCLEAR MAGNETIC RESONANCE IMAGING DIBRA S.P.A. (IT) 2002-01-29 US disclosed