Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 13/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30120115 | 0.95 | CRBN (0.43) | IKZF2CRBNDDB1IKZF1ADRA2A | |
| SCHEMBL24125788 | 0.95 | CRBN (0.43) | IKZF2CRBNDDB1IKZF1ADRA2A | |
| Hydrochloric Acid SCHEMBL29197710 | 0.94 | CRBN (0.42) | IKZF2CRBNDDB1IKZF1ADRA2A | |
| SCHEMBL29197004 | 0.88 | CRBN (0.48) | IKZF2CRBNDDB1IKZF1ADRA2A | |
| Trifluoroacetic Acid SCHEMBL30112300 | 0.87 | IKZF2 (0.49) | IKZF2CRBNDDB1POLB | |
| SCHEMBL24881395 | 0.86 | CRBN (0.42) | IKZF2CRBNDDB1IKZF1ADRA2A | |
| SCHEMBL29094549 | 0.86 | CRBN (0.40) | IKZF2CRBNDDB1IKZF1ADRA2A | |
| Trifluoroacetic Acid SCHEMBL30112407 | 0.84 | CRBN (0.46) | IKZF2CRBNDDB1POLB | |
| Trifluoroacetic Acid SCHEMBL23538681 | 0.83 | CRBN (0.46) | IKZF2CRBNDDB1 | |
| Trifluoroacetic Acid SCHEMBL29253424 | 0.83 | CRBN (0.46) | IKZF2CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888108-B | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116891502-A | EGFR degrading agent | 上海齐鲁制药研究中心有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116888108-A | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022194269-A1 | NOVEL EGFR DEGRADATION AGENT | 上海齐鲁制药研究中心有限公司 | 2022-09-22 | — | — | WO | disclosed |