Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.43 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.41 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24125788 | 1.00 | CRBN (0.43) | CRBNDDB1IKZF2IKZF1POLB | |
| Hydrochloric Acid SCHEMBL29197710 | 0.99 | CRBN (0.42) | CRBNDDB1IKZF2IKZF1POLB | |
| Trifluoroacetic Acid SCHEMBL29094552 | 0.95 | IKZF2 (0.45) | CRBNDDB1IKZF2IKZF1POLB | |
| SCHEMBL24881395 | 0.91 | CRBN (0.42) | CRBNDDB1IKZF2IKZF1POLB | |
| SCHEMBL29197004 | 0.90 | CRBN (0.48) | CRBNDDB1IKZF2IKZF1POLB | |
| SCHEMBL24880631 | 0.87 | IKZF2 (0.44) | CRBNDDB1IKZF2IKZF1DRD4 | |
| SCHEMBL30376385 | 0.86 | CRBN (0.44) | CRBNDDB1IKZF2IKZF1POLB | |
| SCHEMBL24752828 | 0.86 | CRBN (0.40) | CRBNDDB1IKZF2IKZF1POLB | |
| SCHEMBL26329328 | 0.86 | CRBN (0.46) | CRBNDDB1IKZF2IKZF1POLB | |
| SCHEMBL24125789 | 0.86 | CRBN (0.51) | CRBNDDB1IKZF2IKZF1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4351583-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 Therapeutics, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| EP-4168407-A1 | BRAF DEGRADERS | C4 Therapeutics, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| WO-2022261250-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 THERAPEUTICS, INC. (US) | 2022-12-15 | — | — | WO | disclosed |