Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.36 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30120115 | 0.90 | CRBN (0.43) | CRBNDDB1POLBADRA1DADRA1A | |
| SCHEMBL24125788 | 0.90 | CRBN (0.43) | CRBNDDB1POLBADRA1DADRA1A | |
| SCHEMBL29877207 | 0.90 | CRBN (0.51) | CRBNDDB1POLBADRA1DADRA1A | |
| SCHEMBL24125789 | 0.90 | CRBN (0.51) | CRBNDDB1POLBADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL29197710 | 0.89 | CRBN (0.42) | CRBNDDB1POLBADRA1DADRA1A | |
| Trifluoroacetic Acid SCHEMBL29094552 | 0.88 | IKZF2 (0.45) | CRBNDDB1POLBADRA1DADRA1A | |
| SCHEMBL24881395 | 0.86 | CRBN (0.42) | CRBNDDB1POLBADRA1DADRA1A | |
| SCHEMBL24881088 | 0.83 | DDB1 (0.63) | CRBNDDB1POLB | |
| SCHEMBL29877042 | 0.83 | DDB1 (0.63) | CRBNDDB1POLB | |
| SCHEMBL29094549 | 0.80 | CRBN (0.40) | CRBNDDB1POLBADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940133-A | Therapeutic agents for degradation of mutant BRAF | C4医药公司 | 2024-04-26 | — | — | CN | disclosed |