Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2900654 | 0.87 | KDM4E (0.64) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL2909181 | 0.82 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL2895330 | 0.79 | MEN1 (0.53) | ALDH1A1KMT2ASMN1; SMN2MEN1POLB | |
| SCHEMBL2731359 | 0.74 | KMT2A (0.70) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL2117997 | 0.73 | ALDH1A1 (0.62) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL2909354 | 0.73 | KDM4E (0.66) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL2730985 | 0.72 | KMT2A (0.67) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL2895325 | 0.72 | USP2 (0.64) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL13037514 | 0.70 | ALDH1A1 (0.58) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL11798445 | 0.69 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298324-A1 | Prolyl Hydroxylase Inhibitors | SMITH KLINE BEECHAM CORPORATION (US) | 2010-11-25 | — | — | US | disclosed |
| EP-2240178-A1 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009086044-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITH KLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298324-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | ALDH1A1 204/4885KMT2A 395/4885SMN1; SMN2 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.