Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907443 | 0.93 | TP53 (0.54) | KCNN4KDM4ELMNANPSR1HTT | |
| SCHEMBL639847 | 0.88 | KDM4E (0.50) | KDM4ELMNANPSR1HTTKMT2A | |
| SCHEMBL641038 | 0.85 | KDM4E (0.56) | KDM4ELMNANPSR1HTTKMT2A | |
| SCHEMBL2906933 | 0.84 | NPSR1 (0.53) | KDM4ELMNANPSR1HTTKMT2A | |
| SCHEMBL2907639 | 0.83 | PLA2G2A (0.44) | KDM4ELMNANPSR1HTTKMT2A | |
| SCHEMBL2907759 | 0.83 | PLA2G2A (0.43) | KCNN4LMNAKMT2AALDH1A1GAA | |
| SCHEMBL2903474 | 0.83 | KMT2A (0.42) | KDM4ELMNANPSR1HTTKMT2A | |
| SCHEMBL2908237 | 0.82 | HTT (0.58) | KDM4ELMNANPSR1HTTKMT2A | |
| SCHEMBL638972 | 0.82 | BRD4 (0.41) | KCNN4KDM4ELMNANPSR1HTT | |
| SCHEMBL638729 | 0.82 | PLA2G2A (0.43) | KCNN4KDM4ELMNANPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121627-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-08-18 | — | — | EP | claimed |
| EP-2121627-A1 | BENZIMIDAZOLE DERIVATIVES | Merck Patent GmbH (DE) | 2009-11-25 | — | — | EP | claimed |
| WO-2008101586-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | WO | claimed |