Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 5/20 | 0.34 |
| ▸ | SYK | P43405 | 5/20 | 0.34 |
| ▸ | GSK3A | P49840 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913914 | 0.85 | CRBN (0.42) | CRBNALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL1530802 | 0.83 | CRBN (0.61) | CRBNALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL1530743 | 0.81 | CRBN (0.40) | CRBNALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL2916517 | 0.81 | MEN1 (0.41) | CRBNALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL2913952 | 0.78 | CRBN (0.40) | CRBNALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL2915298 | 0.78 | CRBN (0.56) | CRBNALDH1A1CYP3A4 | |
| SCHEMBL2907652 | 0.78 | CYP3A4 (0.46) | CRBNCYP3A4NR1H4GSK3A | |
| SCHEMBL3763864 | 0.78 | CYP3A4 (0.46) | CRBNALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL2910784 | 0.78 | CRBN (0.41) | CRBNCYP3A4GSK3A | |
| Methyl Alcohol SCHEMBL2913736 | 0.77 | CRBN (0.67) | CRBNCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |