Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912827 | 0.87 | CYP3A4 (0.61) | CYP3A4CRBN | |
| SCHEMBL2910784 | 0.84 | CRBN (0.41) | CYP3A4CRBNCHEK1AURKADAPK3 | |
| SCHEMBL1530532 | 0.83 | CRBN (0.60) | CYP3A4CRBNCHEK1AURKADAPK3 | |
| SCHEMBL2913914 | 0.80 | CRBN (0.42) | CYP3A4CRBNNR1H4 | |
| SCHEMBL3763864 | 0.79 | CYP3A4 (0.46) | CYP3A4CRBN | |
| SCHEMBL2913339 | 0.79 | ALDH1A1 (0.34) | CYP3A4CRBNCHEK1 | |
| SCHEMBL2909912 | 0.78 | CRBN (0.41) | CYP3A4CRBNGSK3ANR1H4 | |
| SCHEMBL2915298 | 0.78 | CRBN (0.56) | CYP3A4CRBNJAK2 | |
| SCHEMBL2492602 | 0.76 | CYP3A4 (0.57) | CYP3A4CRBNCHEK1AURKADAPK3 | |
| SCHEMBL1941190 | 0.76 | CRBN (0.60) | CYP3A4CRBNEPHX2PPARGNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |