Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21225855 | 0.85 | TRPV4 (0.53) | TRPV4PDE10ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL31348088 | 0.85 | TRPV4 (0.53) | TRPV4PDE10ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29014781 | 0.79 | TRPV4 (0.40) | TRPV4LMNA | |
| SCHEMBL28059120 | 0.78 | NOS3 (0.39) | TRPV4SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL1845046 | 0.77 | LRRK2 (0.40) | TRPV4PDE10AALDH1A1 | |
| SCHEMBL5582741 | 0.74 | S1PR4 (0.40) | TRPV4LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL29057683 | 0.74 | TRPV4 (0.36) | TRPV4 | |
| SCHEMBL29118011 | 0.74 | TRIM24 (0.44) | TRPV4LMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL3878940 | 0.73 | PDE10A (0.43) | PDE10ALMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL27931903 | 0.73 | NAPRT (0.50) | TRPV4PDE10ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196804-B | TGF-beta R1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-11-07 | — | — | CN | disclosed |