SCHEMBL2910045

SCHEMBL2910045

O=C(c1ccccc1)c1cccc(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.50
NR1H3 Q13133 1/20 0.50
KCNK3 O14649 1/20 0.49
KCNK9 Q9NPC2 1/20 0.49
AKR1C3 P42330 1/20 0.48
LMNA P02545 4/20 0.46
GAA P10253 2/20 0.46
MAPT P10636 2/20 0.46
ALDH1A1 P00352 3/20 0.43
TAS2R14 Q9NYV8 2/20 0.43
ATM Q13315 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
FABP4 P15090 1/20 0.42
POLB P06746 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
SRD5A2 P31213 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CYP1A2 P05177 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzophenone SCHEMBL28067550 0.98 NR1H2 (0.49) NR1H2NR1H3KCNK3KCNK9AKR1C3
SCHEMBL31052944 0.89 AKR1C3 (0.55) NR1H2NR1H3KCNK3KCNK9AKR1C3
SCHEMBL23041398 0.87 LMNA (0.48) KCNK3KCNK9LMNAGAAALDH1A1
SCHEMBL31369140 0.85 GAA (0.56) NR1H2NR1H3KCNK3KCNK9AKR1C3
SCHEMBL3717986 0.85 GAA (0.56) NR1H2NR1H3KCNK3KCNK9AKR1C3
SCHEMBL16196085 0.85 KCNK3 (0.48) NR1H2NR1H3KCNK3KCNK9LMNA
SCHEMBL1125117 0.83 KAT6A (0.52) NR1H2NR1H3KCNK3KCNK9AKR1C3
SCHEMBL29941229 0.83 KAT6A (0.52) NR1H2NR1H3KCNK3KCNK9AKR1C3
Diphenylsulfane SCHEMBL29164344 0.82 LMNA (0.42) KCNK3KCNK9LMNAGAAALDH1A1
SCHEMBL1195140 0.82 TAS2R14 (0.51) KCNK3KCNK9LMNAGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1289462-C Trifluoromethyl benzols, preparing process and application thereof SHANGHAI HIGH VICTORY SCIENCE (CN) 2006-12-13 CN claimed
CN-1524844-A Trifluoromethyl benzols, preparing process and application thereof 上海赫腾高科技有限公司 2004-09-01 CN claimed
US-5017730-A Process of preparing bis (trifluoromethylphenyl) methanol CENTRAL GLASS COMPANY, LIMITED (JP) 1991-05-21 US claimed
US-12351857-B2 Activity based probes UNIVERSITY OF DUNDEE (GB) 2025-07-08 US disclosed
US-20220267825-A1 ACTIVITY BASED PROBES UNIVERSITY OF DUNDEE (GB) 2022-08-25 US disclosed
EP-4021926-A1 ACTIVITY BASED PROBES University of Dundee (GB) 2022-07-06 EP disclosed
CN-114450295-A Activity-based probes 敦提大学 2022-05-06 CN disclosed
WO-2021038034-A1 ACTIVITY BASED PROBES UNIVERSITY OF DUNDEE (GB) 2021-03-04 WO disclosed
CN-111559959-A Synthetic method of p-trifluoromethylphenol 盐城师范学院 2020-08-21 CN disclosed
US-10558089-B2 Photoalignment composition ROLIC AG (CH) 2020-02-11 US disclosed
CN-110105367-A The manufacturing method of cyclobutane tetracarboxylic acid derivatives 日产化学工业株式会社 2019-08-09 CN disclosed
WO-2009080271-A1 PHOTOALIGNMENT COMPOSITION ROLIC LTD. (CH) 2009-07-02 WO disclosed
CN-1289462-C Trifluoromethyl benzols, preparing process and application thereof SHANGHAI HIGH VICTORY SCIENCE (CN) 2006-12-13 CN disclosed
CN-1524844-A Trifluoromethyl benzols, preparing process and application thereof 上海赫腾高科技有限公司 2004-09-01 CN disclosed
CN-1524844-A Trifluoromethyl benzols, preparing process and application thereof 上海赫腾高科技有限公司 2004-09-01 CN disclosed
CN-1144784-C Diphenyl alkyl-tetrahydropyridines, process for their preparation, and pharmaceutical compositions containing them ��ŵ�Ѻϳ�ʵ���� 2004-04-07 CN disclosed
CN-1240428-A Diphenylalkyl-tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them SANOFI SA (FR) 2000-01-05 CN disclosed
US-5017730-A Process of preparing bis (trifluoromethylphenyl) methanol CENTRAL GLASS COMPANY, LIMITED (JP) 1991-05-21 US disclosed
US-5017730-A Process of preparing bis (trifluoromethylphenyl) methanol CENTRAL GLASS COMPANY, LIMITED (JP) 1991-05-21 US disclosed
EP-0156278-A2 Process for the preparation of symmetrical benzophenones substituted by fluor-containing groups, their use and symmetrical benzophenones substituted by fluor-containing groups BAYER AG (DE) 1985-10-02 EP disclosed