Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 11/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223274 | 0.92 | CDC7 (0.42) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL6744024 | 0.81 | ALDH1A1 (0.40) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL6746991 | 0.77 | BRD4 (0.39) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL6809204 | 0.69 | HSD17B10 (0.50) | MAPK1 | |
| SCHEMBL15690360 | 0.67 | CDC7 (0.53) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL15230864 | 0.67 | MAPK1 (0.59) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL15243650 | 0.67 | CDC7 (0.53) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL15243965 | 0.67 | CDC7 (0.53) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL31607736 | 0.66 | PLK4 (0.49) | CDC7MAPKAPK2CDK9CDK2CDK1 | |
| SCHEMBL6225030 | 0.65 | CDC7 (0.50) | CDC7MAPKAPK2CDK9CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572693-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004058762-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |