Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29101055 | 1.00 | TDP1 (0.43) | TDP1ATMNPSR1KMT2APOLB | |
| SCHEMBL29101097 | 0.93 | SUCNR1 (0.43) | TDP1NPSR1MAPTCA1CA2 | |
| SCHEMBL23827436 | 0.93 | SUCNR1 (0.43) | TDP1NPSR1MAPTCA1CA2 | |
| SCHEMBL23827435 | 0.93 | SUCNR1 (0.43) | TDP1NPSR1MAPTCA1CA2 | |
| SCHEMBL23838013 | 0.93 | CA1 (0.39) | TDP1ATMNPSR1KMT2APOLB | |
| SCHEMBL23827389 | 0.81 | PSMB8 (0.41) | TDP1NPSR1KMT2AMEN1MAPT | |
| SCHEMBL23827392 | 0.81 | PSMB8 (0.41) | TDP1NPSR1KMT2AMEN1MAPT | |
| SCHEMBL22012931 | 0.80 | CA1 (0.48) | TDP1ATMNPSR1KMT2APOLB | |
| SCHEMBL22012933 | 0.80 | CA1 (0.48) | TDP1ATMNPSR1KMT2APOLB | |
| SCHEMBL18990470 | 0.79 | CA12 (0.43) | TDP1ATMNPSR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111171014-B | Monocyclolactam compounds and uses thereof | 南京圣和药业股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-112771040-B | Monocyclic lactam compounds and uses thereof | 南京圣和药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |