Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.76 |
| ▸ | GAA | P10253 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MC4R | P32245 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911010 | 0.87 | CSF1R (1.00) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2911202 | 0.86 | CSF1R (0.70) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2908105 | 0.85 | CSF1R (0.77) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2911839 | 0.85 | CSF1R (0.77) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2910657 | 0.85 | CSF1R (0.79) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2908777 | 0.85 | CSF1R (0.79) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2909677 | 0.83 | MAPT (0.79) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2905926 | 0.83 | CSF1R (0.66) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2911379 | 0.83 | CSF1R (0.66) | CSF1RGAAMEN1KMT2ASLC2A1 | |
| SCHEMBL2912636 | 0.82 | CSF1R (0.75) | CSF1RGAAMEN1KMT2ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |