Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29102774 | 0.85 | HCRTR2 (0.41) | AURKAHCRTR2 | |
| SCHEMBL24387093 | 0.85 | HCRTR2 (0.41) | AURKAHCRTR2 | |
| Hydrochloric Acid SCHEMBL29749900 | 0.84 | HCRTR2 (0.41) | AURKAHCRTR2 | |
| SCHEMBL24387380 | 0.77 | HCRTR2 (0.39) | AURKAHCRTR2 | |
| SCHEMBL29102805 | 0.77 | HCRTR2 (0.39) | AURKAHCRTR2 | |
| SCHEMBL29102897 | 0.73 | HCRTR2 (0.47) | HCRTR2 | |
| SCHEMBL24387104 | 0.73 | HCRTR2 (0.47) | HCRTR2 | |
| SCHEMBL29749959 | 0.73 | HCRTR2 (0.41) | HCRTR2 | |
| SCHEMBL29102745 | 0.72 | L3MBTL1 (0.33) | AURKA | |
| SCHEMBL24529266 | 0.70 | HCRTR2 (0.55) | AURKAHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236938-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-116600803-A | Macrocyclic urea orexin receptor agonists | 默沙东有限责任公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |