Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24140334 | 0.84 | IDO1 (0.47) | IDO1ACP3RETHTR2ACETP | |
| SCHEMBL16866695 | 0.79 | IDO1 (0.44) | IDO1 | |
| SCHEMBL18959593 | 0.79 | IDO1 (0.44) | IDO1 | |
| SCHEMBL2907549 | 0.79 | CA9 (0.38) | HTR2AKDM4EALDH1A1 | |
| SCHEMBL447420 | 0.76 | IDO1 (0.66) | IDO1PIN1PDPK1 | |
| SCHEMBL21300294 | 0.76 | IDO1 (0.66) | IDO1PIN1PDPK1 | |
| SCHEMBL14209228 | 0.76 | IDO1 (0.66) | IDO1PIN1PDPK1 | |
| SCHEMBL3814265 | 0.75 | IDO1 (0.46) | IDO1CYP2A6SRD5A1HTR2APIN1 | |
| SCHEMBL2910014 | 0.74 | PNMT (0.42) | HTR2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2472307 | 0.73 | IDO1 (0.68) | IDO1PDPK1KDM4EGID4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |