SCHEMBL29107293

SCHEMBL29107293

C=CCOc1ccccc1C#Cc1ccc(Br)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIG1 P18858 1/20 0.41
HPGD P15428 3/20 0.40
MAPK1 P28482 2/20 0.40
HSD17B10 Q99714 2/20 0.40
TSHR P16473 1/20 0.40
ALDH1A1 P00352 5/20 0.40
FFAR1 O14842 3/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
KDM4E B2RXH2 3/20 0.39
LMNA P02545 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CYP1A2 P05177 2/20 0.37
SLC22A1 O15245 1/20 0.37
ADRB2 P07550 1/20 0.37
ADRB1 P08588 1/20 0.37
HTR1A P08908 1/20 0.37
CYP2D6 P10635 1/20 0.37
HTR2A P28223 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29107302 0.88 MAPT (0.46) LIG1HPGDMAPK1HSD17B10TSHR
SCHEMBL29107260 0.87 MAPT (0.42) LIG1HPGDMAPK1HSD17B10TSHR
SCHEMBL29107259 0.85 PTGDR2 (0.44) LIG1HPGDMAPK1HSD17B10TSHR
SCHEMBL29107268 0.83 APP (0.49) HPGDMAPK1HSD17B10TSHRALDH1A1
SCHEMBL29107266 0.82 FFAR1 (0.40) LIG1HPGDMAPK1HSD17B10TSHR
SCHEMBL28544945 0.80 MEN1 (0.41) HPGDHSD17B10ALDH1A1FFAR1MEN1
SCHEMBL29107284 0.80 HPGD (0.39) LIG1HPGDMAPK1HSD17B10TSHR
SCHEMBL29107288 0.77 ALDH1A1 (0.50) LIG1HPGDMAPK1HSD17B10TSHR
SCHEMBL30638931 0.76 PTGDR2 (0.46) CYP1A2CYP2D6PTGDR2CYP3A4CYP2C9
SCHEMBL28356528 0.74 FFAR1 (0.55) HPGDMAPK1HSD17B10ALDH1A1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117069684-A Method for synthesizing sulfur-containing alkenyl halogenated benzopyran derivative 温州大学 2023-11-17 CN disclosed