Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | GSK3A | P49840 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912809 | 0.92 | GSK3B (0.37) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2911576 | 0.90 | GSK3B (0.36) | GSK3BGSK3AMEN1KMT2ACDK1 | |
| SCHEMBL2904015 | 0.90 | GSK3B (0.43) | GSK3BGSK3AMAPTKMT2ACDK1 | |
| SCHEMBL2910776 | 0.90 | MAPT (0.37) | GSK3BGSK3AMAPTHTTGAA | |
| SCHEMBL2910224 | 0.86 | GSK3B (0.42) | GSK3BGSK3AHTTCDK1LMNA | |
| SCHEMBL2904400 | 0.86 | ALOX5AP (0.43) | GSK3BGSK3AMAPTHTTGAA | |
| SCHEMBL2912014 | 0.86 | ALOX5AP (0.43) | GSK3BGSK3AMAPTHTTGAA | |
| SCHEMBL2909381 | 0.86 | MAPT (0.38) | GSK3BGSK3AMAPTHTTGAA | |
| SCHEMBL2907210 | 0.86 | MAPT (0.38) | GSK3BGSK3AMAPTHTTGAA | |
| SCHEMBL2914083 | 0.85 | MET (0.35) | GSK3BGSK3AHTTCDK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |