Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31243290 | 0.84 | KMT2A (0.37) | KMT2AGSK3AGSK3BAXL | |
| SCHEMBL2062245 | 0.75 | STK17B (0.36) | KMT2ASTK17BSTK17ACNR2 | |
| SCHEMBL2061642 | 0.74 | OPRL1 (0.39) | KMT2ASTK17BSTK17A | |
| SCHEMBL5246396 | 0.73 | STK17B (0.40) | KMT2ASTK17BSTK17A | |
| SCHEMBL3263094 | 0.72 | XDH (0.33) | — | |
| SCHEMBL2062275 | 0.70 | STK17B (0.38) | STK17BSTK17A | |
| SCHEMBL28189209 | 0.68 | ADORA2A (0.40) | AXL | |
| SCHEMBL3155098 | 0.68 | STK17B (0.36) | KMT2ASTK17BSTK17A | |
| SCHEMBL2062278 | 0.67 | STK17B (0.36) | STK17BSTK17A | |
| SCHEMBL5806420 | 0.67 | GSK3A (0.65) | KMT2AGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |