Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 7/20 | 0.65 |
| ▸ | GSK3B | P49841 | 6/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806176 | 0.87 | GSK3A (0.63) | GSK3AGSK3BAURKAADORA3ADORA1 | |
| SCHEMBL5806156 | 0.87 | GSK3A (0.63) | GSK3AGSK3BAURKAADORA3ADORA1 | |
| SCHEMBL23618787 | 0.84 | GSK3A (0.49) | GSK3AGSK3BAURKAADORA3ADORA1 | |
| SCHEMBL5805693 | 0.82 | GSK3A (0.66) | GSK3AGSK3BAURKAADORA3ADORA1 | |
| SCHEMBL5804955 | 0.80 | GSK3A (1.00) | GSK3AGSK3BAURKA | |
| SCHEMBL23618785 | 0.78 | GSK3A (0.44) | GSK3AGSK3BAURKAADORA3ADORA1 | |
| SCHEMBL2716949 | 0.71 | HSD11B1 (0.41) | GSK3AGSK3B | |
| SCHEMBL23618686 | 0.71 | GSK3A (0.37) | GSK3AGSK3BAURKA | |
| SCHEMBL5805875 | 0.70 | GSK3A (0.47) | GSK3AGSK3BMEN1KMT2AL3MBTL1 | |
| SCHEMBL2910789 | 0.67 | KMT2A (0.38) | GSK3AGSK3BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |