Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 3/20 | 0.32 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906883 | 1.00 | CFTR (0.38) | CFTRCYP2C9GCGRAXLGSK3A | |
| SCHEMBL2907828 | 0.91 | HPGD (0.36) | GSK3AGSK3BSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2912050 | 0.91 | HPGD (0.36) | GSK3AGSK3BSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2910052 | 0.91 | MAPT (0.34) | CFTRAXLGSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2910524 | 0.91 | MAPT (0.34) | CFTRAXLGSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2908179 | 0.90 | MET (0.34) | AXLGSK3AGSK3BSMN1; SMN2MEN1 | |
| SCHEMBL2938731 | 0.90 | MET (0.34) | AXLGSK3AGSK3BSMN1; SMN2MEN1 | |
| SCHEMBL2913577 | 0.89 | AHR (0.37) | GCGRAXLGSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2911914 | 0.89 | AHR (0.37) | GCGRAXLGSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2911391 | 0.89 | GSK3B (0.33) | GSK3AGSK3BSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |