Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 5/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.32 |
| ▸ | FEN1 | P39748 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EIF4E | P06730 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911914 | 1.00 | AHR (0.37) | AHRPDE2AGCGRPDE3APDE10A | |
| SCHEMBL2910232 | 0.91 | MAPT (0.34) | GSK3AGSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2911586 | 0.91 | MAPT (0.34) | GSK3AGSK3BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2913352 | 0.91 | ALOX5AP (0.39) | AXLGSK3AGSK3BALOX5APFEN1 | |
| SCHEMBL2909824 | 0.91 | ALOX5AP (0.39) | AXLGSK3AGSK3BALOX5APFEN1 | |
| SCHEMBL2911193 | 0.90 | MET (0.35) | AXLGSK3AGSK3BALOX5APFEN1 | |
| SCHEMBL2904127 | 0.90 | MET (0.35) | AXLGSK3AGSK3BALOX5APFEN1 | |
| SCHEMBL2906883 | 0.89 | CFTR (0.38) | AHRGCGRAXLGSK3AGSK3B | |
| SCHEMBL2911121 | 0.89 | CFTR (0.38) | AHRGCGRAXLGSK3AGSK3B | |
| SCHEMBL2911770 | 0.89 | GSK3B (0.34) | GSK3AGSK3BSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |