Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SCN2B | O60939 | 6/20 | 0.36 |
| ▸ | SCN1B | Q07699 | 6/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | SCN1A | P35498 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29113535 | 0.87 | LRRK2 (0.40) | LRRK2SCN2BSCN1BSCN9ASCN5A | |
| SCHEMBL29929030 | 0.83 | LRRK2 (0.42) | LRRK2MAPK1SYKKDRMAPK3 | |
| SCHEMBL26980293 | 0.83 | LRRK2 (0.42) | LRRK2MAPK1SYKKDRMAPK3 | |
| SCHEMBL29113545 | 0.83 | LRRK2 (0.36) | LRRK2SCN2BSCN1BSCN9ASCN5A | |
| SCHEMBL29113541 | 0.81 | JAK3 (0.40) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL29929431 | 0.81 | EGFR (0.42) | JAK3 | |
| SCHEMBL26980771 | 0.81 | EGFR (0.42) | JAK3 | |
| SCHEMBL29929725 | 0.80 | CCNT1 (0.41) | LRRK2MAPK1SYKKDRJAK2 | |
| SCHEMBL26980444 | 0.80 | CCNT1 (0.41) | LRRK2MAPK1SYKKDRJAK2 | |
| SCHEMBL29113559 | 0.79 | JAK2 (0.49) | SYKJAK3JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136184-A | Aminopyrimidine compounds and methods of use thereof | 泰拉生物科学公司 | 2023-11-28 | — | — | CN | disclosed |