Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.74 |
| ▸ | ROS1 | P08922 | 7/20 | 0.74 |
| ▸ | EGFR | P00533 | 12/20 | 0.68 |
| ▸ | INSR | P06213 | 3/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | STK25 | O00506 | 1/20 | 0.54 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | CASK | O14936 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.54 |
| ▸ | MUSK | O15146 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29245739 | 0.88 | INSR (0.69) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL26906653 | 0.88 | ALK (0.69) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL29904632 | 0.83 | ALK (0.71) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL26906765 | 0.83 | ALK (0.71) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL29114866 | 0.83 | EGFR (0.70) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL29904622 | 0.83 | EGFR (0.70) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL21846986 | 0.81 | EGFR (1.00) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL22462105 | 0.80 | ALK (0.77) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL29245829 | 0.80 | ALK (0.64) | ALKROS1EGFRINSRIGF1R | |
| SCHEMBL29904644 | 0.80 | ALK (0.68) | ALKROS1EGFRINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120424-A | Pyrimidine derivatives having protein kinase inhibitory activity and therapeutic combinations comprising the same | 泰拉佩克斯有限公司 | 2023-11-24 | — | — | CN | claimed |
| CN-117120424-A | Pyrimidine derivatives having protein kinase inhibitory activity and therapeutic combinations comprising the same | 泰拉佩克斯有限公司 | 2023-11-24 | — | — | CN | disclosed |