Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.53 |
| ▸ | INSR | P06213 | 7/20 | 0.53 |
| ▸ | IGF1R | P08069 | 6/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | STK25 | O00506 | 1/20 | 0.49 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | CASK | O14936 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | MUSK | O15146 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906761 | 0.94 | EGFR (0.66) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906927 | 0.91 | EGFR (0.66) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860292 | 0.90 | EGFR (0.49) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906557 | 0.90 | EGFR (0.53) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860744 | 0.89 | EGFR (0.60) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906604 | 0.89 | EGFR (0.53) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906519 | 0.88 | EGFR (0.77) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860328 | 0.87 | EGFR (0.50) | EGFRALKINSRIGF1RMET | |
| SCHEMBL29904683 | 0.87 | EGFR (0.52) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860404 | 0.87 | EGFR (0.51) | EGFRALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120424-A | Pyrimidine derivatives having protein kinase inhibitory activity and therapeutic combinations comprising the same | 泰拉佩克斯有限公司 | 2023-11-24 | — | — | CN | disclosed |