Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.49 |
| ▸ | INSR | P06213 | 13/20 | 0.49 |
| ▸ | IGF1R | P08069 | 12/20 | 0.49 |
| ▸ | MET | P08581 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | STK10 | O94804 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116840 | 1.00 | EGFR (0.52) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906510 | 0.91 | ALK (0.49) | EGFRALKINSRIGF1RMET | |
| SCHEMBL29114963 | 0.87 | EGFR (0.59) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860744 | 0.86 | EGFR (0.60) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906761 | 0.82 | EGFR (0.66) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860285 | 0.80 | EGFR (0.66) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860756 | 0.79 | EGFR (0.55) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906927 | 0.79 | EGFR (0.66) | EGFRALKINSRIGF1RMET | |
| SCHEMBL30860292 | 0.77 | EGFR (0.49) | EGFRALKINSRIGF1RMET | |
| SCHEMBL26906557 | 0.77 | EGFR (0.53) | EGFRALKINSRIGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |