Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.58 |
| ▸ | RAB9A | P51151 | 10/20 | 0.58 |
| ▸ | NPC1 | O15118 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037583 | 0.87 | SMN1; SMN2 (0.67) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL3419672 | 0.80 | MAPT (0.60) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL11355262 | 0.80 | MAPT (0.63) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL11295618 | 0.78 | MAPT (0.68) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL15201427 | 0.77 | MAPT (0.64) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL6677275 | 0.77 | MAPT (0.73) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL27183258 | 0.77 | MAPT (0.55) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL4931104 | 0.76 | MAPT (0.58) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL8325875 | 0.74 | NQO1 (0.70) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL3721960 | 0.74 | MAPT (0.64) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220081-A2 | GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT | LG Life Sciences Ltd. (KR) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009082152-A2 | GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT | LG LIFE SCIENCES LTD. (KR) | 2009-07-02 | — | — | WO | disclosed |