Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL433070 | 1.00 | POLB (0.49) | POLBSPHK1SCN3ADPP4AR | |
| SCHEMBL4631881 | 0.96 | POLB (0.46) | POLBSPHK1SCN3ADPP4AR | |
| SCHEMBL4705439 | 0.96 | POLB (0.46) | POLBSPHK1SCN3ADPP4AR | |
| SCHEMBL12486018 | 0.84 | VNN1 (0.45) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL17865501 | 0.81 | SPHK1 (0.52) | POLBSPHK1SCN3ADPP4AR | |
| SCHEMBL3594485 | 0.81 | SPHK1 (0.52) | POLBSPHK1SCN3ADPP4AR | |
| SCHEMBL408684 | 0.78 | SPHK1 (0.71) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL5154674 | 0.78 | SPHK1 (0.71) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL408685 | 0.78 | SPHK1 (0.71) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL4701752 | 0.78 | SPHK1 (0.47) | POLBSPHK1SCN3AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051981-B1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-08-25 | — | — | EP | disclosed |
| US-20090239924-A1 | 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-09-24 | — | — | US | disclosed |
| EP-2051981-A1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-04-29 | — | — | EP | disclosed |
| WO-2007138017-A1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239924-A1 | 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | IGF1R, CDK1, CDK15 | POLB 1946/4885SPHK1 2340/4885SCN3A 3483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.