Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892044 | 1.00 | RIPK1 (0.53) | RIPK1NR1H2NR1H3PDE5AGHSR | |
| SCHEMBL29115996 | 1.00 | RIPK1 (0.53) | RIPK1NR1H2NR1H3PDE5AGHSR | |
| SCHEMBL433008 | 0.88 | RIPK1 (0.52) | RIPK1NR1H2NR1H3PDE5ARXRA | |
| SCHEMBL445614 | 0.88 | RIPK1 (0.52) | RIPK1NR1H2NR1H3PDE5ARXRA | |
| SCHEMBL29115943 | 0.88 | RIPK1 (0.40) | RIPK1NR1H2NR1H3GHSR | |
| SCHEMBL29115941 | 0.88 | RIPK1 (0.40) | RIPK1NR1H2NR1H3GHSR | |
| SCHEMBL29331595 | 0.85 | RORC (0.41) | NR1H2NR1H3PDE5AGRM5GRM1 | |
| SCHEMBL642698 | 0.85 | NR1H2 (0.50) | RIPK1NR1H2NR1H3RXRAGPR119 | |
| SCHEMBL29115999 | 0.85 | NR1H2 (0.50) | RIPK1NR1H2NR1H3RXRAGPR119 | |
| SCHEMBL17067869 | 0.84 | RIPK1 (0.73) | RIPK1NR1H2NR1H3PDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157285-A | Pharmaceutical compounds as ubiquitin-specific protease 19 (USP 19) inhibitors | 阿尔麦克探索有限公司 | 2023-12-01 | — | — | CN | disclosed |