Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892012 | 1.00 | RIPK1 (0.52) | RIPK1TACR1GPR119NR1H2NR1H3 | |
| SCHEMBL29116081 | 0.89 | RIPK1 (0.49) | RIPK1TACR1GPR119NR1H2NR1H3 | |
| SCHEMBL29891858 | 0.89 | RIPK1 (0.49) | RIPK1TACR1GPR119NR1H2NR1H3 | |
| SCHEMBL29891697 | 0.89 | RIPK1 (0.49) | RIPK1TACR1GPR119NR1H2NR1H3 | |
| SCHEMBL29115969 | 0.87 | RIPK1 (0.48) | RIPK1GPR119NR1H2NR1H3RXRA | |
| SCHEMBL20012078 | 0.87 | RIPK1 (0.48) | RIPK1GPR119NR1H2NR1H3RXRA | |
| SCHEMBL29116144 | 0.85 | RIPK1 (0.54) | RIPK1GPR119NR1H2NR1H3JAK2 | |
| SCHEMBL27077230 | 0.84 | RIPK1 (0.49) | RIPK1TACR1PDE5A | |
| SCHEMBL469686 | 0.83 | RIPK1 (0.73) | RIPK1NR1H2NR1H3JAK2NTRK1 | |
| SCHEMBL17067869 | 0.83 | RIPK1 (0.73) | RIPK1NR1H2NR1H3JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157285-A | Pharmaceutical compounds as ubiquitin-specific protease 19 (USP 19) inhibitors | 阿尔麦克探索有限公司 | 2023-12-01 | — | — | CN | disclosed |