Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 5/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.31 |
| ▸ | ABL1 | P00519 | 4/20 | 0.31 |
| ▸ | EGFR | P00533 | 4/20 | 0.31 |
| ▸ | HCK | P08631 | 4/20 | 0.31 |
| ▸ | KDR | P35968 | 4/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.31 |
| ▸ | MTOR | P42345 | 4/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29121967 | 0.83 | MAPT (0.36) | IRAK4RXFP1MAPTALDH1A1HTT | |
| SCHEMBL29122457 | 0.83 | MAPT (0.38) | IRAK4RXFP1MAPTALDH1A1HTT | |
| SCHEMBL29123043 | 0.82 | POLB (0.40) | RXFP1MAPTALDH1A1HTTPIK3CA | |
| SCHEMBL29121652 | 0.78 | KDM4C (0.39) | IRAK4SRCSPRMAPTALDH1A1 | |
| SCHEMBL29122475 | 0.78 | KDM4C (0.39) | IRAK4SRCSPRMAPTALDH1A1 | |
| SCHEMBL29122103 | 0.78 | KDM4C (0.39) | IRAK4SRCSPRMAPTALDH1A1 | |
| SCHEMBL29122916 | 0.76 | L3MBTL1 (0.40) | IRAK4SRCSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL29121571 | 0.76 | L3MBTL1 (0.40) | IRAK4SRCSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL29122594 | 0.76 | L3MBTL1 (0.40) | IRAK4SRCSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL29122614 | 0.74 | POLB (0.35) | RXFP1MAPTALDH1A1HTTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
| CN-117120419-A | KLK5 bicyclic heteroaromatic inhibitors | 拜奥克里斯特制药公司 | 2023-11-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | KLK5, KLK1, KLKB1 | IRAK4 1876/4885SRC 3403/4885SLC2A1 4340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.