Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.42 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.48 |
| ▸ | TERT | O14746 | 3/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL16060422 | 0.87 | EP300 (0.63) | EP300PTPN1TERTPPARGPPARD | |
| SCHEMBL4135302 | 0.87 | — | — | |
| SCHEMBL5568117 | 0.87 | — | — | |
| SCHEMBL13656778 | 0.84 | EP300 (0.58) | EP300PTPN1TERTPPARGPPARD | |
| SCHEMBL6673248 | 0.84 | EP300 (0.58) | EP300PTPN1TERTPPARGPPARD | |
| SCHEMBL23658645 | 0.84 | EP300 (0.58) | EP300PTPN1TERTPPARGPPARD | |
| SCHEMBL12744410 | 0.84 | EP300 (0.58) | EP300PTPN1TERTPPARGPPARD | |
| SCHEMBL8476412 | 0.84 | EP300 (0.58) | EP300PTPN1TERTPPARGPPARD | |
| SCHEMBL14224382 | 0.84 | EP300 (0.58) | EP300PTPN1TERTPPARGPPARD | |
| SCHEMBL22346319 | 0.84 | EP300 (0.58) | EP300PTPN1TERTPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141663-B | Additive for improving lubricating property of gasoline and gasoline composition | 中国石油化工股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-115537242-B | Diesel antiwear agent composition, preparation method thereof and diesel oil composition | 中国石油化工股份有限公司 | 2023-11-10 | — | — | CN | disclosed |