Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | PELI1 | Q96FA3 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2914308 | 0.87 | CYP3A4 (0.47) | CYP3A4CRBNMETIKBKBCHUK | |
| SCHEMBL2913176 | 0.85 | CYP3A4 (0.46) | CYP3A4CRBNMETPELI1PDGFRB | |
| SCHEMBL2910162 | 0.85 | CYP3A4 (0.46) | CYP3A4CRBN | |
| SCHEMBL2913825 | 0.84 | CYP3A4 (0.47) | CYP3A4CRBNMETIKBKBCHUK | |
| SCHEMBL2915424 | 0.83 | CYP3A4 (0.49) | CYP3A4CRBN | |
| SCHEMBL2915016 | 0.83 | CYP3A4 (0.47) | CYP3A4CRBNIKBKBCHUK | |
| SCHEMBL2913786 | 0.83 | CYP3A4 (0.47) | CYP3A4CRBN | |
| SCHEMBL1530346 | 0.83 | CRBN (0.52) | CYP3A4CRBNMETFABP4FABP5 | |
| SCHEMBL1530342 | 0.83 | CRBN (0.52) | CYP3A4CRBNMETFABP4FABP5 | |
| SCHEMBL2910644 | 0.83 | CRBN (0.49) | CRBNMETFABP4FABP5IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-2203430-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | Abbott Laboratories (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009039135-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |