Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 6/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.32 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913825 | 0.90 | CYP3A4 (0.47) | CYP3A4IKBKBCHUKCRBNCYP17A1 | |
| SCHEMBL2913176 | 0.89 | CYP3A4 (0.46) | CYP3A4CRBNMET | |
| SCHEMBL2912679 | 0.87 | CYP3A4 (0.46) | CYP3A4IKBKBCHUKCRBNMET | |
| SCHEMBL2913615 | 0.85 | CYP3A4 (0.46) | CYP3A4CRBN | |
| SCHEMBL2913786 | 0.84 | CYP3A4 (0.47) | CYP3A4CRBN | |
| SCHEMBL2915016 | 0.84 | CYP3A4 (0.47) | CYP3A4IKBKBCHUKCRBN | |
| SCHEMBL2915424 | 0.84 | CYP3A4 (0.49) | CYP3A4CRBN | |
| SCHEMBL2910162 | 0.84 | CYP3A4 (0.46) | CYP3A4CRBN | |
| SCHEMBL479100 | 0.83 | CYP3A4 (0.61) | CYP3A4CRBN | |
| SCHEMBL1530298 | 0.82 | CRBN (0.53) | CYP3A4IKBKBCHUKCRBNCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |