Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479100 | 0.89 | CYP3A4 (0.61) | CYP3A4CRBNPTGS2 | |
| SCHEMBL2913786 | 0.89 | CYP3A4 (0.47) | CYP3A4CRBNPTGS2TEAD2FLT3 | |
| SCHEMBL2915016 | 0.89 | CYP3A4 (0.47) | CYP3A4CRBNPTGS2TEAD2FLT3 | |
| Water SCHEMBL2484221 | 0.88 | CYP3A4 (0.60) | CYP3A4CRBNPTGS2 | |
| Water SCHEMBL2908232 | 0.88 | CYP3A4 (0.59) | CYP3A4CRBN | |
| SCHEMBL2913043 | 0.85 | CYP3A4 (0.51) | CYP3A4CRBNPTGS2 | |
| SCHEMBL2914308 | 0.84 | CYP3A4 (0.47) | CYP3A4CRBN | |
| SCHEMBL2912679 | 0.83 | CYP3A4 (0.46) | CYP3A4CRBN | |
| SCHEMBL2910162 | 0.83 | CYP3A4 (0.46) | CYP3A4CRBN | |
| SCHEMBL2913176 | 0.83 | CYP3A4 (0.46) | CYP3A4CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-2203430-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | Abbott Laboratories (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039135-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |