SCHEMBL29127366

SCHEMBL29127366

COc1cc(C)c(N2CN(c3c(C)cc(OC)cc3C)C(C)=C2C)c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
CYP3A4 P08684 3/20 0.35
HTR3E A5X5Y0 1/20 0.35
HTR3B O95264 1/20 0.35
HTR3A P46098 1/20 0.35
HTR3D Q70Z44 1/20 0.35
HTR3C Q8WXA8 1/20 0.35
HPGD P15428 2/20 0.34
PKM P14618 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
CYP19A1 P11511 1/20 0.33
NQO2 P16083 1/20 0.33
ADRB1 P08588 1/20 0.32
CYP1A1 P04798 1/20 0.32
CYP1B1 Q16678 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PTPN1 P18031 2/20 0.32
MEN1 O00255 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29127365 0.98 ALDH1A1 (0.39) ALDH1A1CYP3A4HTR3EHTR3BHTR3A
SCHEMBL22430527 0.71 CYP11B1 (0.48) ALDH1A1PKMSMN1; SMN2L3MBTL1MEN1
SCHEMBL22430562 0.70 CYP11B1 (0.44) PKMSMN1; SMN2L3MBTL1MEN1TSHR
SCHEMBL3439540 0.67 ALDH1A1 (0.53) ALDH1A1CYP3A4HPGDFFAR4CYP19A1
SCHEMBL2117991 0.67 HTR3A (0.63) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL2633660 0.66 ALDH1A1 (0.59) ALDH1A1CYP3A4HPGDFFAR4CYP1A1
SCHEMBL12326164 0.66 ALDH1A1 (0.59) ALDH1A1CYP3A4HPGDFFAR4CYP1A1
Hydrochloric Acid SCHEMBL10903841 0.66 ALDH1A1 (0.50) ALDH1A1CYP3A4HPGDSMN1; SMN2FFAR4
SCHEMBL2955343 0.64 ALDH1A1 (0.56) ALDH1A1CYP3A4HPGDFFAR4CYP1A1
SCHEMBL282134 0.62 ALDH1A1 (0.53) ALDH1A1CYP3A4HPGDFFAR4NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115286547-B Method for synthesizing aryl benzyl thioether compound 苏州大学 2023-11-03 CN disclosed
CN-115286547-B Method for synthesizing aryl benzyl thioether compound 苏州大学 2023-11-03 CN disclosed
CN-115286547-A Method for synthesizing aryl benzyl sulfide compound 苏州大学 2022-11-04 CN disclosed
CN-115286547-A Method for synthesizing aryl benzyl sulfide compound 苏州大学 2022-11-04 CN disclosed