Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31569359 | 0.78 | LMNA (0.39) | RORCMETAP1ATR | |
| SCHEMBL31570445 | 0.70 | ATR (0.42) | RORCMETAP1ATRBRS3CYP17A1 | |
| SCHEMBL24752319 | 0.69 | METAP1 (0.38) | RORCMETAP1ATRBRS3CYP17A1 | |
| SCHEMBL30853060 | 0.69 | METAP1 (0.38) | RORCMETAP1ATRBRS3CYP17A1 | |
| SCHEMBL28584577 | 0.69 | ATR (0.45) | METAP1ATRCYP17A1BRD9 | |
| SCHEMBL18818309 | 0.68 | KDM1A (0.39) | RORCATREPHX2ACACBACACA | |
| SCHEMBL22523291 | 0.68 | ATR (0.47) | METAP1ATRCYP17A1BRD9 | |
| SCHEMBL31160906 | 0.68 | ATR (0.44) | METAP1ATRCYP17A1BRD9 | |
| SCHEMBL10330551 | 0.68 | ATR (0.47) | METAP1ATRCYP17A1BRD9 | |
| SCHEMBL29706266 | 0.68 | ATR (0.47) | METAP1ATRCYP17A1BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116940552-A | Spirocyclic hexane derivatives, pharmaceutical compositions containing them and their use as anti-apoptotic inhibitors | 法国施维雅药厂 | 2023-10-24 | — | — | CN | disclosed |