SCHEMBL29128158

SCHEMBL29128158

CC(C)(C)OC(=O)N1CCCC(COc2ccc(S(C)(=O)=O)cc2)C1

nearest known ligand 0.75

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 16/20 0.64
SCN9A Q15858 1/20 0.55
CHEK2 O96017 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26967015 1.00 GPR119 (0.64) GPR119SCN9ACHEK2
SCHEMBL26966817 0.97 GPR119 (0.63) GPR119SCN9ACHEK2
SCHEMBL29128224 0.97 GPR119 (0.63) GPR119SCN9ACHEK2
SCHEMBL29128107 0.87 SCN9A (0.57) GPR119SCN9ACHEK2
SCHEMBL31071721 0.86 SCN9A (0.52) GPR119SCN9ACHEK2
SCHEMBL26966917 0.86 SCN9A (0.52) GPR119SCN9ACHEK2
SCHEMBL1769253 0.86 CHEK2 (0.56) GPR119SCN9ACHEK2
SCHEMBL17729089 0.86 CHEK2 (0.56) GPR119SCN9ACHEK2
SCHEMBL29128127 0.85 ALDH1A1 (0.48) GPR119
SCHEMBL3443787 0.85 CHEK2 (0.56) SCN9ACHEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116997546-A APOL1 inhibitors and methods of use 梅兹治疗公司 2023-11-03 CN disclosed