SCHEMBL29128490

SCHEMBL29128490

O=c1[nH]cc(CSCCCOc2cccc(Br)c2)[nH]1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.42
HTT P42858 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
SOD1 P00441 1/20 0.42
ALDH1A1 P00352 5/20 0.39
KMT2A Q03164 3/20 0.39
MAPT P10636 1/20 0.39
KDM4E B2RXH2 5/20 0.38
LMNA P02545 1/20 0.38
MEN1 O00255 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
MAOB P27338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30799922 1.00 RAB9A (0.42) RAB9AHTTL3MBTL1SOD1ALDH1A1
SCHEMBL29128423 0.86 RAB9A (0.42) RAB9AHTTL3MBTL1SOD1ALDH1A1
SCHEMBL30800046 0.86 RAB9A (0.42) RAB9AHTTL3MBTL1SOD1ALDH1A1
SCHEMBL29128546 0.85 KCNA3 (0.41) RAB9AL3MBTL1ALDH1A1MAPTKDM4E
SCHEMBL29128517 0.81 HTR1B (0.35) RAB9AL3MBTL1ALDH1A1MAPTLMNA
SCHEMBL30799972 0.80 DAO (0.44) ALDH1A1KMT2AKDM4EMEN1CYP1A2
SCHEMBL29128397 0.80 DAO (0.44) ALDH1A1KMT2AKDM4EMEN1CYP1A2
SCHEMBL29128313 0.78 CYP1A2 (0.32) HTTALDH1A1KMT2AMAPTKDM4E
SCHEMBL30800062 0.78 CYP1A2 (0.32) HTTALDH1A1KMT2AMAPTKDM4E
SCHEMBL29128527 0.78 HCAR2 (0.36) RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117263862-A Phenol-1, 3-oxazole/dihydroimidazole-2-ketone/thioketone compound and synthesis and application thereof 吉首大学 2023-12-22 CN disclosed