SCHEMBL29128696

SCHEMBL29128696

[CH2]C(=O)NC(=O)Nc1cc(F)ccc1OC

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.58
MEN1 O00255 4/20 0.58
MAPT P10636 3/20 0.58
HTT P42858 2/20 0.58
PYGL P06737 5/20 0.56
L3MBTL1 Q9Y468 1/20 0.51
HTR3E A5X5Y0 1/20 0.51
HTR3B O95264 1/20 0.51
HTR3A P46098 1/20 0.51
HTR3D Q70Z44 1/20 0.51
HTR3C Q8WXA8 1/20 0.51
ALDH1A1 P00352 4/20 0.49
CYP1A2 P05177 3/20 0.48
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
CYP2C19 P33261 2/20 0.46
CYP3A4 P08684 1/20 0.46
IRAK4 Q9NWZ3 1/20 0.46
ATM Q13315 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29128655 0.82 ALDH1A1 (0.67) KMT2AMEN1MAPTPYGLL3MBTL1
SCHEMBL29128682 0.82 PYGL (0.56) KMT2AMEN1MAPTHTTPYGL
SCHEMBL31078153 0.80 ALDH1A1 (0.59) KMT2AMEN1MAPTHTTPYGL
SCHEMBL3870167 0.78 KMT2A (0.60) KMT2AMEN1MAPTHTTPYGL
SCHEMBL23512599 0.75 CYP1A2 (0.49) KMT2AMEN1MAPTHTTPYGL
SCHEMBL9383033 0.73 KMT2A (0.51) KMT2AMEN1MAPTHTTPYGL
SCHEMBL29660728 0.72 MAPT (0.53) KMT2AMEN1MAPTHTTPYGL
SCHEMBL15601956 0.72 KMT2A (0.51) KMT2AMEN1MAPTHTTPYGL
SCHEMBL18500908 0.72 ALDH1A1 (0.74) KMT2AMEN1MAPTPYGLL3MBTL1
SCHEMBL20984166 0.72 KMT2A (0.52) KMT2AMEN1MAPTHTTPYGL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117263873-A 1, 4-benzodiazepine compounds and application thereof in preparation of antitumor drugs 复旦大学 2023-12-22 CN disclosed