Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.65 |
| ▸ | CDK1 | P06493 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | CDK7 | P50613 | 11/20 | 0.53 |
| ▸ | CCNH | P51946 | 9/20 | 0.53 |
| ▸ | CDK9 | P50750 | 7/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.52 |
| ▸ | CCNK | O75909 | 6/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.52 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.52 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204774 | 0.83 | EGFR (0.67) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL29613510 | 0.83 | EGFR (0.67) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL17150617 | 0.82 | EGFR (0.72) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL4513070 | 0.81 | ABL1 (0.64) | EGFRCDK1CDK7CCNHCDK9 | |
| SCHEMBL23624997 | 0.79 | EGFR (0.62) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL18078641 | 0.79 | EGFR (0.75) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL18078646 | 0.78 | EGFR (0.73) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL30524068 | 0.78 | EGFR (0.66) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL25328688 | 0.77 | EGFR (0.63) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL24900623 | 0.77 | CDK1 (0.60) | EGFRCDK1KDRCDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117279636-A | Methods and compounds for modulating myotonic muscular dystrophy type 1 | 设计治疗公司 | 2023-12-22 | — | — | CN | disclosed |
| EP-4259133-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022126000-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2022-06-16 | — | — | WO | disclosed |