Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL2908714 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4ERAB9ANPC1TP53 | |
| Ammonia Solution, Strong SCHEMBL2909794 | 0.83 | GSK3B (0.41) | DPP4MEN1TSHRKMT2ALMNA | |
| Ammonia Solution, Strong SCHEMBL2906802 | 0.82 | GSK3B (0.41) | DPP4TSHRKMT2AHTTLMNA | |
| Ammonia Solution, Strong SCHEMBL2912310 | 0.82 | HRH3 (0.41) | DPP4DPP8DPP9GSK3AGSK3B | |
| Ammonia Solution, Strong SCHEMBL2911403 | 0.79 | FNTA (0.37) | SMN1; SMN2KDM4ERAB9ANPC1GAA | |
| Ammonia Solution, Strong SCHEMBL2912015 | 0.77 | GSK3B (0.42) | DPP4MEN1TSHRKMT2ALMNA | |
| SCHEMBL2907499 | 0.77 | GSK3B (0.49) | SMN1; SMN2KDM4EGAAMEN1KMT2A | |
| SCHEMBL2908225 | 0.75 | LMNA (0.57) | SMN1; SMN2KDM4ERAB9AGAAMEN1 | |
| SCHEMBL2910737 | 0.75 | CYP2C19 (0.54) | SMN1; SMN2RAB9AMEN1KMT2AHTT | |
| SCHEMBL6028956 | 0.73 | GSK3B (0.38) | RAB9ANPC1HPGDTSHRGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |