Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909849 | 0.95 | NPC1 (0.46) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL3649621 | 0.84 | NPC1 (0.40) | NPC1RAB9APOLBSMN1; SMN2IDO1 | |
| SCHEMBL2912514 | 0.83 | TP53 (0.40) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL2912392 | 0.82 | EPHX2 (0.48) | NPC1RAB9ALMNASIGMAR1EPHX1 | |
| SCHEMBL3649148 | 0.81 | NPC1 (0.42) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2914348 | 0.81 | LMNA (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2914853 | 0.81 | MEN1 (0.46) | NPC1RAB9APOLBLMNAEPHX1 | |
| SCHEMBL2907059 | 0.80 | C3AR1 (0.39) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2907076 | 0.80 | LMNA (0.47) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL3651382 | 0.79 | CNR2 (0.38) | NPC1RAB9APOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222645-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-09-01 | — | — | EP | claimed |
| WO-2009062874-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-22 | — | — | WO | claimed |
| EP-2222645-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009062874-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-22 | — | — | WO | disclosed |